Author: Lithanatudom, P.
Paper Title Page
WEPOTK036 Progress on Electron Beam Optimization for FLASH Radiotherapy Experiment at Chiang Mai University 2146
SUSPMF078   use link to see paper's listing under its alternate paper code  
 
  • K. Kongmali, P. Apiwattanakul, S. Rimjaem, J. Saisut, C. Thongbai
    Chiang Mai University, Chiang Mai, Thailand
  • P. Apiwattanakul, N. Kangrang
    Chiang Mai University, PBP Research Facility, Chiang Mai, Thailand
  • M. Jitvisate
    Suranaree University of Technology, Nakhon Ratchasima, Thailand
  • P. Lithanatudom
    IST, Chiang Mai, Thailand
 
  At present, one of diseases that kills many people worldwide is cancer. The FLASH radiotherapy (RT) is a promising cancer treatment under study. It involves the fast delivery of RT at much higher dose rates than those currently used in clinical practice. The very short time of exposure leads to the destruction of the cancer cells, while the nearby normal cells are less damaged as compared with conventional RT. This work focuses on study of FLASH-RT experiment using electron beams produced from the accelerator system at the PBP-CMU Electron Linac Laboratory. The structure and properties of our electron pulses with microbunches in picosecond time scale and macropulses in microsecond time scale match well to FLASH-RT requirement. To optimize the condition for experiment, the electron beam simulations are performed by varying energy, charge and bunch length. The 25 MeV electrons energy before hitting the window for 50 and 100 pC bunch length have a bunch length of 1.16 and 1.97 ps. The transverse rms beam sizes of 50 pC and 100 pC bunch charges have the differences between ASTRA and GEANT4 from 7.90 % to 34.0 %. The optimized electron beam properties from this study will be used as the guideline for further simulation and experiment preparation.  
DOI • reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2022-WEPOTK036  
About • Received ※ 08 June 2022 — Revised ※ 14 June 2022 — Accepted ※ 20 June 2022 — Issue date ※ 22 June 2022
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THPOMS026 Monte Carlo Simulation of Electron Beam in Phantom Water for Radiotherapy Application 3011
SUSPMF128   use link to see paper's listing under its alternate paper code  
 
  • P. Apiwattanakul, C. Phueng-ngern, S. Rimjaem, J. Saisut
    Chiang Mai University, Chiang Mai, Thailand
  • P. Lithanatudom
    IST, Chiang Mai, Thailand
  • P. Nimmanpipug, S. Rimjaem, J. Saisut
    ThEP Center, Commission on Higher Education, Bangkok, Thailand
 
  Radiotherapy (RT) is an effective treatment that can control the growth of cancer cells. There is a hypothesis suggests that secondary electrons with an energy of a few eV produced from RT play an important role on cancer’s DNA strand break. In this study, the Monte Carlo simulation of electron beam irradiation in phantom water is performed to investigate the production of low-energy electrons. Electron beams produced from an radio-frequency linear accelerator (RF linac) are used in this study. The accelerator can generate the electron beam with adjustable energy of up to 4 MeV and adjustable repetition rate of up to 200 Hz. With these properties, the electron dose can be varied. We used ASTRA software to simulate the electron beam dynamics in the accelerator and GEANT4 toolkit for studying interactions of electrons in water. The energy of electrons decreases from MeV scale to keV-eV scale as they travel in the water. From simulations, the dose distribution and depth in phantom water were obtained for the electron dose of 1, 3, 5, 10, 25, and 50 Gy. Further study on effect of low-energy electron beam with these dose values on cancer DNAs will be performed with GEANT4-DNA simulation.  
DOI • reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2022-THPOMS026  
About • Received ※ 08 June 2022 — Revised ※ 16 June 2022 — Accepted ※ 17 June 2022 — Issue date ※ 25 June 2022
Cite • reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)