IPAC2022 - List of Authors (Sapinski, M.)

Paper	Title	Page
TUOZGD2	A Compact Synchrotron for Advanced Cancer Therapy with Helium and Proton Beams	811
THPOMS021	use link to see paper's listing under its alternate paper code
	M. Vretenar, M.E. Angoletta, J.C.C.M. Borburgh, L. Bottura, K. Paļskis, R.L. Taylor, G. Tranquille CERN, Meyrin, Switzerland E. Benedetto SEEIIST, Geneva, Switzerland G. Bisoffi INFN/LNL, Legnaro (PD), Italy M. Sapinski PSI, Villigen PSI, Switzerland
	Recent years have seen an increased interest in the use of helium for radiation therapy of cancer. Helium ions can be more precisely delivered to the tumour than protons or carbon ions, presently the only beams licensed for treatment, with a biological effectiveness between the two. The accelerator required for helium is considerably smaller than a standard carbon ion synchrotron. To exploit the potential of helium therapy and of other emerging particle therapy techniques, in the framework of the Next Ion Medical Machine Study (NIMMS) at CERN the design of a compact synchrotron optimised for acceleration of proton and helium beams has been investigated. The synchrotron is based on a new magnet design, profits from a novel injector linac, and can provide both slow and fast extraction for conventional and FLASH therapy. Production of mini-beams, and operation with multiple ions for imaging and treatment are also considered. This accelerator is intended to become the main element of a facility devoted to a programme of cancer research and treatment with proton and helium beams, to both cure patients and contribute to the assessment of helium beams as a new tool to fight cancer.
	Slides TUOZGD2 [1.940 MB]
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2022-TUOZGD2
About •	Received ※ 20 May 2022 — Revised ※ 11 June 2022 — Accepted ※ 16 June 2022 — Issue date ※ 11 July 2022
Cite •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

THPOMS049	Energy Comparison of Room Temperature and Superconducting Synchrotrons for Hadron Therapy	3080
	G. Bisoffi INFN/LNL, Legnaro (PD), Italy E. Benedetto, M. Karppinen, M.R. Khalvati, M. Vretenar, R. van Weelderen CERN, Meyrin, Switzerland M.G. Pullia, G. Venchi CNAO Foundation, Pavia, Italy L. Rossi INFN/LASA, Segrate (MI), Italy M. Sapinski PSI, Villigen PSI, Switzerland M. Sorbi Universita’ degli Studi di Milano & INFN, Segrate, Italy R.U. Valente La Sapienza University of Rome, Rome, Italy
	The yearly energy requirements of normal conducting (NC) and superconducting (SC) magnet options of a new hadron therapy (HT) facility are compared. Special reference is made to the layouts considered for the proposed SEEIIST facility. Benchmarking with the NC CNAO HT centre in Pavia (Italy) was carried out. The energy comparison is centred on the different synchrotron solutions, assuming the same injector and lines in the designs. The beam current is more than a factor 10 higher with respect to present generation facilities. This allows efficient ’multi-energy extraction’ (MEE), which shortens the therapy treatment and is needed especially in the SC option, because of the slow magnet ramping time. Hence, power values of the facility in the traditional mode were converted into MEE ones, for the sake of a fair stepwise comparison between NC and SC magnets. The use of cryocoolers and a liquefier are also compared, for synchrotron refrigeration. This study shows that a NC facility operated in MEE mode requires the least average energy, followed by the SC synchrotron solution with a liquefier, while the most energy intensive solution is the SC one with cryocoolers.
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2022-THPOMS049
About •	Received ※ 20 May 2022 — Revised ※ 17 June 2022 — Accepted ※ 28 June 2022 — Issue date ※ 10 July 2022
Cite •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

THPOMS019	Slow Extraction Modelling for NIMMS Hadron Therapy Synchrotrons	2988
SUSPMF125	use link to see paper's listing under its alternate paper code
	R.L. Taylor CERN, Meyrin, Switzerland E. Benedetto, M. Sapinski SEEIIST, Geneva, Switzerland J. Pasternak Imperial College of Science and Technology, Department of Physics, London, United Kingdom
	Funding: This study was (partially) supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 101008548 (HITRIplus). The Next Ion Medical Machine Study (NIMMS) is an umbrella R&D programme for CERN accelerator technologies targeting advanced accelerator options for proton and light ion therapy. In collaboration with the European program HITRIplus, one area of study is slow extraction which is required to deliver a uniform beam spill for radiotherapy treatment. Several techniques use the third-order resonance to extract hadrons; these include betatron core driven extraction and radiofrequency knock-out. Flexible simulations tools using these techniques were prepared and initially benchmarked with results from the literature that used the Proton-Ion Medical Machine Study (PIMMS) design. The limits of the current PIMMS design were then pushed to evaluate its compatibility to deliver >10x higher intensity ion beams, and using increased extraction rates.
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2022-THPOMS019
About •	Received ※ 19 May 2022 — Revised ※ 15 June 2022 — Accepted ※ 17 June 2022 — Issue date ※ 21 June 2022
Cite •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

Paper

Title

Page

TUOZGD2

A Compact Synchrotron for Advanced Cancer Therapy with Helium and Proton Beams

811

THPOMS021

use link to see paper's listing under its alternate paper code

M. Vretenar, M.E. Angoletta, J.C.C.M. Borburgh, L. Bottura, K. Paļskis, R.L. Taylor, G. Tranquille
CERN, Meyrin, Switzerland
E. Benedetto
SEEIIST, Geneva, Switzerland
G. Bisoffi
INFN/LNL, Legnaro (PD), Italy
M. Sapinski
PSI, Villigen PSI, Switzerland

Recent years have seen an increased interest in the use of helium for radiation therapy of cancer. Helium ions can be more precisely delivered to the tumour than protons or carbon ions, presently the only beams licensed for treatment, with a biological effectiveness between the two. The accelerator required for helium is considerably smaller than a standard carbon ion synchrotron. To exploit the potential of helium therapy and of other emerging particle therapy techniques, in the framework of the Next Ion Medical Machine Study (NIMMS) at CERN the design of a compact synchrotron optimised for acceleration of proton and helium beams has been investigated. The synchrotron is based on a new magnet design, profits from a novel injector linac, and can provide both slow and fast extraction for conventional and FLASH therapy. Production of mini-beams, and operation with multiple ions for imaging and treatment are also considered. This accelerator is intended to become the main element of a facility devoted to a programme of cancer research and treatment with proton and helium beams, to both cure patients and contribute to the assessment of helium beams as a new tool to fight cancer.

Slides TUOZGD2 [1.940 MB]

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2022-TUOZGD2

About •

Received ※ 20 May 2022 — Revised ※ 11 June 2022 — Accepted ※ 16 June 2022 — Issue date ※ 11 July 2022

Cite •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

THPOMS049

Energy Comparison of Room Temperature and Superconducting Synchrotrons for Hadron Therapy

3080

G. Bisoffi
INFN/LNL, Legnaro (PD), Italy
E. Benedetto, M. Karppinen, M.R. Khalvati, M. Vretenar, R. van Weelderen
CERN, Meyrin, Switzerland
M.G. Pullia, G. Venchi
CNAO Foundation, Pavia, Italy
L. Rossi
INFN/LASA, Segrate (MI), Italy
M. Sapinski
PSI, Villigen PSI, Switzerland
M. Sorbi
Universita’ degli Studi di Milano & INFN, Segrate, Italy
R.U. Valente
La Sapienza University of Rome, Rome, Italy

The yearly energy requirements of normal conducting (NC) and superconducting (SC) magnet options of a new hadron therapy (HT) facility are compared. Special reference is made to the layouts considered for the proposed SEEIIST facility. Benchmarking with the NC CNAO HT centre in Pavia (Italy) was carried out. The energy comparison is centred on the different synchrotron solutions, assuming the same injector and lines in the designs. The beam current is more than a factor 10 higher with respect to present generation facilities. This allows efficient ’multi-energy extraction’ (MEE), which shortens the therapy treatment and is needed especially in the SC option, because of the slow magnet ramping time. Hence, power values of the facility in the traditional mode were converted into MEE ones, for the sake of a fair stepwise comparison between NC and SC magnets. The use of cryocoolers and a liquefier are also compared, for synchrotron refrigeration. This study shows that a NC facility operated in MEE mode requires the least average energy, followed by the SC synchrotron solution with a liquefier, while the most energy intensive solution is the SC one with cryocoolers.

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2022-THPOMS049

About •

Received ※ 20 May 2022 — Revised ※ 17 June 2022 — Accepted ※ 28 June 2022 — Issue date ※ 10 July 2022

Cite •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

THPOMS019

Slow Extraction Modelling for NIMMS Hadron Therapy Synchrotrons

2988

SUSPMF125

use link to see paper's listing under its alternate paper code

R.L. Taylor
CERN, Meyrin, Switzerland
E. Benedetto, M. Sapinski
SEEIIST, Geneva, Switzerland
J. Pasternak
Imperial College of Science and Technology, Department of Physics, London, United Kingdom

Funding: This study was (partially) supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 101008548 (HITRIplus).
The Next Ion Medical Machine Study (NIMMS) is an umbrella R&D programme for CERN accelerator technologies targeting advanced accelerator options for proton and light ion therapy. In collaboration with the European program HITRIplus, one area of study is slow extraction which is required to deliver a uniform beam spill for radiotherapy treatment. Several techniques use the third-order resonance to extract hadrons; these include betatron core driven extraction and radiofrequency knock-out. Flexible simulations tools using these techniques were prepared and initially benchmarked with results from the literature that used the Proton-Ion Medical Machine Study (PIMMS) design. The limits of the current PIMMS design were then pushed to evaluate its compatibility to deliver >10x higher intensity ion beams, and using increased extraction rates.

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2022-THPOMS019

About •

Received ※ 19 May 2022 — Revised ※ 15 June 2022 — Accepted ※ 17 June 2022 — Issue date ※ 21 June 2022

Cite •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)