JACoW is a publisher in Geneva, Switzerland that publishes the proceedings of accelerator conferences held around the world by an international collaboration of editors.
TY - CONF AU - Schedler, M. AU - Bräuer, M. AU - Busold, S. ED - Zimmermann, Frank ED - Tanaka, Hitoshi ED - Sudmuang, Porntip ED - Klysubun, Prapong ED - Sunwong, Prapaiwan ED - Chanwattana, Thakonwat ED - Petit-Jean-Genaz, Christine ED - Schaa, Volker R.W. TI - Beam Diagnostics for FLASH RT in the Varian ProBeam System J2 - Proc. of IPAC2022, Bangkok, Thailand, 12-17 June 2022 CY - Bangkok, Thailand T2 - International Particle Accelerator Conference T3 - 13 LA - english AB - FLASH RT is a novel ultra-high dose rate radiation therapy technique with the potential of sparing radiation induced damages to healthy tissue while keeping tumor control unchanged. Recent studies indicate that this so-called FLASH effect occurs when applying high doses of several Grays in a fraction of a second only, and thus significantly faster than with conventionally available radiation therapy systems today. Varian’s ProBeam system has been enabled to deliver ultra-high beam currents for FLASH treatments at 250 MeV beam energy. The first clinical trial is currently conducted at Cincinnati Children’s Hospital Medical Center and all involved human patients have been successfully irradiated at FLASH dose rates, operating the system at cw cyclotron beam currents of up to 400 nA. With these modifications, treatment times could be reduced down to less than a second. First automated switching between conventional and FLASH operation modes has been demonstrated in non-clinical environment, including switching of the dose monitor system characteristics and all involved beam diagnostics. Furthermore, for an improved online beam current control system with full control over dose rate in addition to dose Varian has demonstrated first promising results that may improve future applications. PB - JACoW Publishing CP - Geneva, Switzerland SP - 2951 EP - 2953 KW - controls KW - radiation KW - proton KW - operation KW - target DA - 2022/07 PY - 2022 SN - 2673-5490 SN - 978-3-95450-227-1 DO - doi:10.18429/JACoW-IPAC2022-THPOMS007 UR - https://jacow.org/ipac2022/papers/thpoms007.pdf ER -